Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

Inflammation, Cytokine, Signal Transduction +13

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

L. Marty, Marc Piechaczyk, S.El Sabrouty et al. · Nucleic Acids Research · 1985 · 2.2K citations · Full text

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension.

Rubin M. Tuder, Bertron Μ. Groves, David B. Badesch et al. · PubMed · 1994 · 802 citations · Full text

Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

Marc Humbert, Gianpaola Monti, F Brénot et al. · American Journal of Respiratory and Critical Care Medicine · 1995 · 777 citations

Acute Lung Injury, Hypertension, Interleukin-6 Serum Concentrations +18

Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension.

S. D. Lee, Kenneth R. Shroyer, Neil Markham et al. · Journal of Clinical Investigation · 1998 · 427 citations · Full text

Hypertension, Vascular Disease, Endothelial Cells +19