International Journal of Oncology · 1993 · 14 citations · 0 references
MedicineImmunologyPathologyImmunopathologyTumor ImmunologyTumor PathologyCytokine-mediated PathologyCytokines In Tumor ImmunityImmune-mediated DiseaseInflammatory SignalingNecrosisTumor ImmunopathologyAdministration Of Monoclonal AntibodiesCytotoxic NecrosisSpontaneous Tumor RegressionTumor Necrosis ResponseTumor-associated Cytokines
Animals which reject a histiocytoma show extensive necrosis of the tumor and produce TNF in an autologus manner without any external stimulation. An excellent correlation between the expression of TNF and the levels of TNF in circulation during tumor regression is demonstrated. TNF purified from the sera of tumor regressing animals is cytotoxic to AK-5 cells in vitro. Anti TNF antibody neutralizes the cytotoxic activity of TNF against AK-5 cells in vitro. Injection of monoclonal antibodies against TNF into tumor bearing animals delays the appearance of necrosis in AK-5 tumors thereby suggesting a direct role for TNF in AK-5 rejection.