Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP), cyperquat (MPP+) and paraquat on isolated mitochondria from rat striatum, cortex and liver

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

J. William Langston, Philip L. Ballard, James W. Tetrud et al. · Science · 1983 · 4.9K citations

Life Sciences, Neuroscience, Pharmacology +14

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

William J. Nicklas, I Vyas, Richard E. Heikkila · Life Sciences · 1985 · 1.3K citations

Life Sciences, Biochemistry, Neuroscience +14

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

Kan Chiba, Anthony J. Trevor, Neal Castagnoli · Biochemical and Biophysical Research Communications · 1984 · 1.1K citations

Life Sciences, Neuroscience, Pharmacology +14

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

Richard E. Heikkila, Lawrence Manzino, Felicitas S. Cabbat et al. · Nature · 1984 · 1K citations

Medicine, Neuroscience, Pharmacology +14

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

Richard E. Heikkila, Arthur Hess, Roger C. Duvoisin · Science · 1984 · 1K citations

Medicine, Neuroscience, Pharmacology +17