Concepedia

Ischemic Stroke Injury Is Reduced in Mice Lacking a Functional NADPH Oxidase

Claire E. Walder, Simon P. Green, Walter C. Darbonne, Joanne Mathias, Julie Rae, Mary C. Dinauer, John T. Curnutte, George Thomas

Stroke · 1997 · 351 citations · 33 references

DOI

Abstract

Brain injury was reduced in mice lacking a functional NADPH oxidase in both the central nervous system and peripheral leukocytes, suggesting a pivotal role for the NADPH oxidase in the pathogenesis of ischemia-reperfusion injury in the brain.

References

33

Tissue Plasminogen Activator for Acute Ischemic Stroke

The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group · New England Journal of Medicine · 1995 · 11.6K citations

, , +17

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.4K citations · Full text

, , +18

Tissue Destruction by Neutrophils

New England Journal of Medicine · 1989 · 3.6K citations

, , +19

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

David S. Bredt, Solomon H. Snyder · Proceedings of the National Academy of Sciences · 1990 · 3.3K citations

, , +17

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

Zhihong Huang, Paul L. Huang, Nariman Panahian et al. · Science · 1994 · 1.6K citations

, , +23