Passive transfer of narcolepsy: Anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt Rd, Aurélie Bertin, M Jalfre · PubMed · 1977 · 3.3K citations

Medicine, Pharmacology, Psychiatry +17

Narcolepsy in orexin Knockout Mice

Richard M. Chemelli, Jon T. Willie, Christopher M. Sinton et al. · Cell · 1999 · 3.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Ling Lin, Juliette Faraco, Robin Li et al. · Cell · 1999 · 2.6K citations · Full text

Medicine, Neurology, Neuroscience +13

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

Christelle Peyron, Juliette Faraco, William M. Rogers et al. · Nature Medicine · 2000 · 2.1K citations

Life Sciences, Neurology, Neuroscience +13

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Junko Hara, Carsten T. Beuckmann, Tadahiro Nambu et al. · Neuron · 2001 · 1.4K citations · Full text

Life Sciences, Neurobiology, Neuroscience +13