Chronic Intermittent Ethanol Exposure and Withdrawal Alters (3<i>α</i>,5<i>α</i>)‐3‐Hydroxy‐Pregnan‐20‐One Immunostaining in Cortical and Limbic Brain Regions of<scp>C</scp>57<scp>BL</scp>/6<scp>J</scp>Mice

Abstract

These data suggest that specific neuroadaptations in 3α,5α-THP levels may be present in regions of brain that mediate anxiety, stress, and reinforcement relevant to EtOH dependence. The changes that occur at different time points likely modulate neurocircuitry involved in EtOH withdrawal as well as the elevated drinking observed after CIE exposure.