Fatal Hepatitis Associated with Isoflurane Exposure and CYP2A6 Autoantibodies

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

Philippe Beaune, Patrick M. Dansette, Daniel Mansuy et al. · Proceedings of the National Academy of Sciences · 1987 · 324 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.

Ulrich M. Zanger, Hans-Peter Hauri, J Loeper et al. · Proceedings of the National Academy of Sciences · 1988 · 239 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Oxidation of Acetaminophen to Its Toxic Quinone Imine and Nontoxic Catechol Metabolites by Baculovirus-Expressed and Purified Human Cytochromes P450 2E1 and 2A6

Weiqiao Chen, Luke L. Koenigs, Stella J. Thompson et al. · Chemical Research in Toxicology · 1998 · 224 citations

Medicine, Pharmacology, Toxicology +16

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

Mohammed Bourdi, Dominique Larrey, J Nataf et al. · Journal of Clinical Investigation · 1990 · 209 citations · Full text

Life Sciences, Immunology, Autoimmunity +14

Human Cytochrome P450 2E1 Is a Major Autoantigen Associated with Halothane Hepatitis

Mohammed Bourdi, Weiqiao Chen, Raimund M. Peter et al. · Chemical Research in Toxicology · 1996 · 189 citations

Medicine, Pharmacology, Hepatology +13