Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

Chris G. Parsons, G. Quack, I. Bresink et al. · Neuropharmacology · 1995 · 312 citations

Life Sciences, Neuroscience, Pharmacology +10

The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. IV. Protective indices

Wolfgang Löscher, Björn Nolting · Epilepsy Research · 1991 · 157 citations

Medicine, Pharmacology, Pharmacotherapy +13

Low Doses of NMDA Receptor Antagonists Synergistically Increase the Anticonvulsant Effect of the AMPA Receptor Antagonist NBQX in the Kindling Model of Epilepsy

Wolfgang Löscher, Chris Rundfeldt, Dagmar Hönack · European Journal of Neuroscience · 1993 · 99 citations

Medicine, Neuroscience, Pharmacology +14

Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: A potential mechanism for the anticonvulsive effects

Yangzheng Feng, Michael H. LeBlanc, S. Regunathan · Neuroscience Letters · 2005 · 80 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Effects of the non‐NMDA antagonists NBQX and the 2,3‐benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil

Wolfgang Löscher, Dagmar Hönack · British Journal of Pharmacology · 1994 · 68 citations · Full text

Medicine, Neurobiology, Pharmacotherapy +14