5-Aminomethylbenzimidazoles as potent ITK antagonists

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

Edward M. Schaeffer, Jayanta Debnath, George Yap et al. · Science · 1999 · 401 citations

Life Sciences, Immunology, Molecular Biology +17

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells

Deborah J. Fowell, Kanade Shinkai, Xiang Liao et al. · Immunity · 1999 · 309 citations · Full text

Life Sciences, Immunology, Molecular Biology +16

Mutation of Tec family kinases alters T helper cell differentiation

Edward M. Schaeffer, George Yap, Carol M. Lewis et al. · Nature Immunology · 2001 · 175 citations

Life Sciences, Immunology, Molecular Biology +14

Three Mechanistically Distinct Kinase Assays Compared: Measurement of Intrinsic ATPase Activity Identified the Most Comprehensive Set of ITK Inhibitors

Mohammed A. Kashem, Richard M. Nelson, Jeffrey D. Yingling et al. · SLAS DISCOVERY · 2006 · 135 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors

Roger J. Snow, Asitha Abeywardane, Scot Campbell et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16