Concepedia

Iron(II)-mediated rearrangement of 1,2,4-trioxanes into 1,2-diol monoesters via 1,5-hydrogen transfer

A. J. BLOODWORTH, Aneela Shah

Tetrahedron Letters · 1995 · 33 citations · 9 references

DOI

Concepts

References

9

Regiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu).

Gary H. Posner, Chang Ho Oh · Journal of the American Chemical Society · 1992 · 193 citations

, , +8

Mechanism-Based Design, Synthesis, and in vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance of a Carbon-Centered Radical for Antimalarial Activity

Gary H. Posner, Chang Ho Oh, Dasong Wang et al. · Journal of Medicinal Chemistry · 1994 · 187 citations

, , +10

Evidence for Fe(IV):O in the Molecular Mechanism of Action of the Trioxane Antimalarial Artemisinin

Gary H. Posner, Jared N. Cumming, Poonsakdi Ploypradith et al. · Journal of the American Chemical Society · 1995 · 173 citations

, , +8

Synthesis, Structure, and Antimalarial Activity of Some Enantiomerically Pure, <i>cis</i>‐fused cyclopenteno‐1,2,4‐trioxanes

Charles W. Jefford, Shigeo Kohmoto, Danielle Jaggi et al. · Helvetica Chimica Acta · 1995 · 102 citations

, , +17

The Decomposition of <i>cis</i>‐Fused Cyclopenteno‐1,2,4‐Trioxanes induced by Ferrous Salts and some oxophilic reagents

Charles W. Jefford, France Favarger, M. Graça H. Vicente et al. · Helvetica Chimica Acta · 1995 · 64 citations

, , +8