Clinical Monoclonal B Lymphocytosis versus Rai 0 Chronic Lymphocytic Leukemia: A Comparison of Cellular, Cytogenetic, Molecular, and Clinical Features

Fortunato Morabito, Laura Mosca, Giovanna Cutrona, Luca Agnelli, Giacomo Tuana, Manuela Ferracin, Barbara Zagatti, Marta Lionetti, Sonia Fabris, Francesco Maura,

Clinical Cancer Research · 2013 · 64 citations · 34 references

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Abstract

Our study based on a prospective series of patients indicates that no major differences exist between the circulating cells from cMBL and Rai0-CLL, at least based on a comparison of the markers used in the study. This possibly suggests that the two conditions mainly differ in the initial size of the monoclonal cell population, which may influence the subsequent timing of clonal expansion and clinical manifestations.

References

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