CrystEngComm · 2010 · 104 citations · 32 references
4-Hydroxybenzoic AcidMedicinal ChemistryPharmaceutical SciencePhotochromismPhotochemistryNitrofurantoin-4-hydroxybenzoic AcidDrug DiscoveryNatural SciencesMedicineOrganic ChemistryPharmaceutical Co-crystallizing AbilityChemistryAntimicrobial CompoundPharmacologyPharmaceutical ChemistryBiomolecular EngineeringCo-crystal Displays
Pharmaceutical co-crystallizing ability of an antibiotic agent, nitrofurantoin, is screened with three isomeric monohydroxybenzoic acids. 1 : 1 co-crystal of nitrofurantoin-4-hydroxybenzoic acid has been prepared and structurally characterized. Further, the co-crystal displays superior physicochemical and photo-stability compared to nitrofurantoin.
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