Characterization, physicochemical and photo-stability of a co-crystal involving an antibioticdrug, nitrofurantoin, and 4-hydroxybenzoic acid

Abstract

Pharmaceutical co-crystallizing ability of an antibiotic agent, nitrofurantoin, is screened with three isomeric monohydroxybenzoic acids. 1 : 1 co-crystal of nitrofurantoin-4-hydroxybenzoic acid has been prepared and structurally characterized. Further, the co-crystal displays superior physicochemical and photo-stability compared to nitrofurantoin.