DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr, +2

Journal of Biological Chemistry

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jiřina Bártková, Zuzana Hořejšı́, Karen Koed, +10

Nature

ChromatinTumor BiologyGenome InstabilityDna DamageOncogenic Agent +9

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Emmy P. Rogakou, Chye Boon, Christophe E. Redon, +1

The Journal of Cell Biology

Megabase ChromatinDna DamageGeneticsRadiation EffectRadiation Exposure +20

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

Sandeep Burma, Benjamin P. Chen, Michael Murphy, +2

Journal of Biological Chemistry

DNA Damage Foci at Dysfunctional Telomeres

Hiroyuki Takai, Agata Smogorzewska, Titia de Lange

Current Biology

ChromatinGenome InstabilityDna DamageGenetic DisorderNatural Sciences +6

Genomic Instability in Mice Lacking Histone H2AX

Arkady Celeste, Simone Petersen, Peter Romanienko, +18

Science

Histone ModificationsDna DamageEpigenetic ChangeGeneticsMolecular Genetics +16

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Arkady Celeste, Óscar Fernández-Capetillo, Michael J. Kruhlak, +6

Nature Cell Biology

Histone ModificationsChromatinGenome InstabilityChromatin RemodelingNatural Sciences +13

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Olga A. Sedelnikova, Izumi Horikawa, Drazen B. Zimonjic, +3

Nature Cell Biology

Knockout MouseChromatinGenome InstabilityUnrepairable Double-strand BreaksDna Damage +8

DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

Óscar Fernández-Capetillo, Hua-Tang Chen, Arkady Celeste, +11

Nature Cell Biology

Histone ModificationsChromatinGenome InstabilityChromatin StructureChromatin Remodeling +8

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

Craig H. Bassing, Katrin F. Chua, JoAnn Sekiguchi, +11

Proceedings of the National Academy of Sciences