Concepedia

Pharmacodynamic and Pharmacokinetic Characterization of Interactions between Levetiracetam and Numerous Antiepileptic Drugs in the Mouse Maximal Electroshock Seizure Model: An Isobolographic Analysis

Jarogniew J. Łuszczki, Marta Andres‐Mach, Piotr Czuczwar, Anna Cioczek‐Czuczwar, Neville Ratnaraj, Philip N. Patsalos, Stanisław J. Czuczwar

Epilepsia · 2006 · 61 citations · 60 references

DOI

Abstract

These preclinical data would suggest that LEV in combination with TPM is associated with beneficial anticonvulsant pharmacodynamic interactions. Similar, but less profound effects were seen with OXC and CBZ.

References

60

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Early Identification of Refractory Epilepsy

Patrick Kwan, Martin J. Brodie · New England Journal of Medicine · 2000 · 5.1K citations · Full text

A simplified method of evaluating dose-effect experiments.

Frank Wilcoxon · PubMed · 1949 · 2K citations

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

Berkley A. Lynch, Nathalie Lambeng, Karl Nocka et al. · Proceedings of the National Academy of Sciences · 2004 · 1.6K citations · Full text

, , +15

The problem of synergism and antagonism of combined drugs.

S. Loewe · PubMed · 1953 · 984 citations

, , +7