Concepedia

Validated gene expression biomarker analysis for biopsy‐based clinical trials in ulcerative colitis

Brigid S. Boland, D. L. Boyle, William J. Sandborn, Gary S. Firestein, Barrett G. Levesque, Joshua Hillman, Bing Zhang, James Proudfoot, Lars Eckmann, Peter B. Ernst,

Alimentary Pharmacology & Therapeutics · 2014 · 12 citations · 25 references

DOIFull text

Open access

Abstract

Our data suggest that systematic measurement of inflammatory biomarkers at the mRNA level can be a valuable tool for hypothesis testing, and assessment of clinical activity and response to therapy in ulcerative colitis.

References

25

R: A Language and Environment for Statistical Computing

R Core Team · 2000 · 352.8K citations · Full text

Linear Mixed-Effects Models using 'Eigen' and S4

Douglas M. Bates, Martin Maechler, Benjamin M. Bolker et al. · 2015 · 6K citations

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Small Sample Inference for Fixed Effects from Restricted Maximum Likelihood

Michael G. Kenward, James Roger · Biometrics · 1997 · 4.4K citations

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Coated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis

Kenneth W. Schroeder, William J. Tremaine, Duane M. Ilstrup · New England Journal of Medicine · 1987 · 3K citations

A Kenward-Roger Approximation and Parametric Bootstrap Methods for Tests in Linear Mixed Models - The<i>R</i>Package<b>pbkrtest</b>

Ulrich Halekoh, Søren Højsgaard · Journal of Statistical Software · 2014 · 1.3K citations · Full text

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