IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

Florian R. Greten, Lars Eckmann, Tim F. Greten, +5

Cell

InflammationIkkβ Links InflammationCytokineMucosal ImmunologyColitis-associated Cancer +12

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

Sergei I. Grivennikov, Eliad Karin, Janoš Terzić, +8

Cancer Cell

InflammationMucosal ImmunologyColitis-associated CancerImmunologyGastroenterology +8

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Sergei I. Grivennikov, Kepeng Wang, Daniel Mucida, +18

Nature

CytokineMedicineImmunologyPathologyAdenoma-linked Barrier Defects +7

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

Hyun Chae Jung, Lars Eckmann, Shen K. Yang, +4

Journal of Clinical Investigation

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

Shipra Vaishnava, Cassie L. Behrendt, Anisa S. Ismail, +2

Proceedings of the National Academy of Sciences

Chronic Inflammatory DiseasesDysbiosisHost-microbe InteractionsImmunologyGastroenterology +17

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

Yi Duan, Cristina Llorente, Sonja Lang, +43

Nature

DysbiosisHepatologyMedicineLiver PhysiologyLiver Disease +3

<i>Nod2</i> Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing

Shin Maeda, Li‐Chung Hsu, Hongjun Liu, +5

Science

Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry

Lars Eckmann, Martin F. Kagnoff, Joshua Fierer

Infection and Immunity

Microbial PathogensImmunologyMucosal Inflammatory ResponseBacterial PathogensCervical Epithelial Cells +16

NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

Florian R. Greten, Melek C. Arkan, Julia Bollrath, +16

Cell

InflammationCytokineMolecular PhysiologyNegative RegulatorImmune Regulation +7

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

Jong‐Dae Lee, Ji‐Hun Mo, Kyoko Katakura, +11

Nature Cell Biology

InflammationSignal TransductionMucosal ImmunologyT-regulatory CellColonic Homeostasis +9