Concepedia

Brønsted Acid/Rhodium(II) Cooperative Catalytic Asymmetric Three‐Component Aldol‐Type Reaction for the Synthesis of 3‐Amino Oxindoles

Lei Ren, Xiao‐Lei Lian, Liu‐Zhu Gong

Chemistry - A European Journal · 2013 · 120 citations · 79 references

DOI

Concepts

Abstract

Cooperation is key! Chiral Brønsted acid/rhodium(II) cooperative catalysis enabled an enantioselective three-component aldol-type reaction of 3-diazo oxindoles and anilines with glyoxylates to give highly functionalized and structurally diverse 3-amino oxindoles in high stereoselectivity (>20:1 d.r., 99 % ee; see scheme).

References

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