Cooperative Catalysis with Chiral Brønsted Acid-Rh₂(OAc)₄: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines

Abstract

An asymmetric three-component reaction of diazo compounds and alcohols with imines catalyzed cooperatively by a rhodium complex and a chiral Brønsted acid provides a general and efficient entry to beta-amino-alpha-hydroxyl acid derivatives in high yields with excellent stereoselectivities.