Concepedia

Drug-Resistant Epilepsy

Patrick Kwan, Steven C. Schachter, Martin J. Brodie

New England Journal of Medicine · 2011 · 1.1K citations · 48 references

DOI

Concepts

Abstract

Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.

References

48

Early Identification of Refractory Epilepsy

Patrick Kwan, Martin J. Brodie · New England Journal of Medicine · 2000 · 5.2K citations · Full text

, , +17

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

Patrick Kwan, Alexis Arzimanoglou, Anne T. Berg et al. · Epilepsia · 2009 · 4.7K citations

, , +17

A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy

Samuel Wiebe, Warren T. Blume, John P. Girvin et al. · New England Journal of Medicine · 2001 · 3.5K citations · Full text

, , +9

Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies

Josep Dalmau, Amy J. Gleichman, Ethan G. Hughes et al. · The Lancet Neurology · 2008 · 3.5K citations · Full text

, , +14

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

Elizabeth Neal, Hannah Chaffe, Ruby H. Schwartz et al. · The Lancet Neurology · 2008 · 1.2K citations

, , +12