Modulation of Intracellular Ca2+ Concentration in Brain Microvascular Endothelial Cells in vitro by Acoustic Cavitation

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Grzegorz Grynkiewicz, Martin Poenie, Roger Y. Tsien · Journal of Biological Chemistry · 1985 · 21.7K citations · Full text

Natural Sciences, Biochemistry, Chemistry +17

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

Kullervo Hynynen, Nathan McDannold, Natalia Vykhodtseva et al. · Radiology · 2001 · 1.5K citations

Medicine, Biomedical Engineering, Radiology +17

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

Kullervo Hynynen, Nathan McDannold, Nickolai Sheikov et al. · NeuroImage · 2004 · 686 citations

Engineering, Biomedical Engineering, Neuroscience +12

Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

Manabu Kinoshita, Nathan McDannold, Ferenc A. Jólesz et al. · Proceedings of the National Academy of Sciences · 2006 · 649 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles

Nickolai Sheikov, Nathan McDannold, Natalia Vykhodtseva et al. · Ultrasound in Medicine & Biology · 2004 · 620 citations

Medicine, Biophysics, Neuroscience +14