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Life SciencesCardiologyCell BiologyApoptosisCell SignalingSignal TransductionAnthracycline CardiotoxicityApoptosis RegulationApoptotic SignalingCell DeathDeath ReceptorsExtrinsic Apoptotic PathwayDoxorubicin CardiotoxicityFas LigandFas Ligand-mediated ApoptosisFas Receptor SignalingFas-associated Death Domain ProteinFas-fas Ligand Mediated KillingFas-mediated Apoptosis Resistance
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Michael A. Frohman, Michael Dush, Gail R. Martin · Proceedings of the National Academy of Sciences · 1988 · 4.6K citations · Full text
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
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