A Phytochemical in the Edible Tamogi-take Mushroom (<i>Pleurotus cornucopiae</i>),<scp>D</scp>-Mannitol, Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats

Abstract

D-Mannitol, one of the main phytochemicals of the edible Tamogi-take mushroom (Pleurotus cornucopiae), was found to inhibit an angiotensin I converting enzyme (ACE). The antihypertensive effect of D-mannitol and a hot water extract of Tamogi-take mushroom was demonstrated in spontaneously hypertensive rats (SHR) by oral administration.