Concepedia

Synthesis and biological evaluations of a monomethylauristatin E glucuronide prodrug for selective cancer chemotherapy

Thibaut Legigan, Jonathan Clarhaut, Brigitte Renoux, Isabelle Tranoy‐Opalinski, Arnaud Monvoisin, Christophe Jayle, Jérôme Alsarraf, Mikaël Thomas, Sébastien Papot

European Journal of Medicinal Chemistry · 2013 · 30 citations · 21 references

DOI

Concepts

References

21

Development of potent monoclonal antibody auristatin conjugates for cancer therapy

Svetlana O. Doronina, Brian E. Toki, Michael Torgov et al. · Nature Biotechnology · 2003 · 1.2K citations

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Elucidation of the mechanism enabling tumor selective prodrug monotherapy.

Klaus Bosslet, Rainer H. Straub, Matthias Blumrich et al. · PubMed · 1998 · 226 citations

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Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity

T.A. Connors, M. E. Whisson · Nature · 1966 · 141 citations

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Design of Self-Immolative Linkers for Tumour-Activated Prodrug Therapy

Isabelle Tranoy‐Opalinski, Antony E. Fernandes, Mikaël Thomas et al. · Anti-Cancer Agents in Medicinal Chemistry · 2008 · 83 citations

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Prodrugs of Anthracyclines for Use in Antibody-Directed Enzyme Prodrug Therapy

Jean‐Claude Florent, Xia Dong, Gilbert Gaudel et al. · Journal of Medicinal Chemistry · 1998 · 81 citations

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