Pain · 2000 · 179 citations · 4 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyPain ManagementPain MedicineAdverse Effects Of AnalgesicsAnalgesiaAnalgesic PharmacologyIntrathecal Drug DeliveryOpioid AnalgesicsPharmacologic Pain TherapyAnalgesic EffectsIntrathecal AdministrationIntrathecal Analgesic TherapyIntrathecal Ziconotide TherapyPain PharmacologyPharmacologic Intrathecal TherapySerious Adverse Drug ReactionsSerious Adverse Events
The omega-conopeptide, ziconotide, is an N-type calcium-channel blocker that has been shown to produce antinociception in animals using formalin and hot-plate tests. Initial reports of intrathecal administration of ziconotide in cancer and AIDS patients whose pain was unrelieved with opioids demonstrated analgesic efficacy. Although adverse effects were reported, these appeared to be easily managed through dose reduction or symptomatic treatment. This clinical report describes the experiences of three patients with serious adverse effects associated with intrathecal ziconotide.
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Peptide Neurotoxins from Fish-Hunting Cone Snails
Baldomero M. Olivera, William R. Gray, Regina D. Zeikus et al. · Science · 1985 · 748 citations