Propofol improved neurobehavioral outcome of cerebral ischemia–reperfusion rats by regulating Bcl-2 and Bax expression

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

Life Sciences, Cell Biology, Molecular Biology +12

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

Life Sciences, Cell Biology, Molecular Biology +13

Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model

Maj‐Lis Smith, George Bendek, Nils Dahlgren et al. · Acta Neurologica Scandinavica · 1984 · 737 citations

Medicine, Neuroscience, Pharmacology +11

Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat

Yi Li, Cecylia Powers, Ning Jiang et al. · Journal of the Neurological Sciences · 1998 · 190 citations

Life Sciences, Neurobiology, Neuroscience +13

Expression of Apoptosis-Regulatory Genes in Renal Proximal Tubular Epithelial Cells Exposed to High Ambient Glucose and in Diabetic Kidneys

Alberto Ortíz, Fuad N. Ziyadeh, Eric G. Neilson · Journal of Investigative Medicine · 1997 · 181 citations

Medicine, Pathology, Physiology +17