A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

Randall K. Saiki, Stephen J. Scharf, Fred Faloona et al. · Science · 1985 · 9K citations

Medicine, Genetics, Molecular Genetics +17

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

Kary B. Mullis, Fred Faloona · Methods in enzymology on CD-ROM/Methods in enzymology · 1987 · 5.7K citations

Life Sciences, Genetics, Molecular Biology +11

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

Concepción Almoguera, Darryl Shibata, Kathleen Forrester et al. · Cell · 1988 · 2.1K citations

Medicine, Molecular Genetics, Oncology +10

Prevalence of ras gene mutations in human colorectal cancers

Johannes L. Bos, Eric R. Fearon, Stanley R. Hamilton et al. · Nature · 1987 · 1.9K citations

Medicine, Genetics, Oncology +14

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

Kathleen Forrester, Concepción Almoguera, Kyuhyung Han et al. · Nature · 1987 · 1.1K citations

Medicine, Cancer Biology, Oncology +12