Journal of Materials Chemistry B · 2014 · 27 citations · 37 references
Natural SciencesMaterials EngineeringMaterials ScienceBiocompatibilityBiomaterialsPolymer EngineeringAntibacterial AgentsAntimicrobial BiomaterialsCoating TechnologyCoatingsSurface ModificationSurface Modification Of BiomaterialsAntibacterial BiomaterialsAntibacterial CoatingsAntibacterial MaterialsAntibacterial Surface ModificationAntimicrobial BiocompatibilityBiocompatibility ImprovementChemical Vapor Deposition CoatingsImmobilized Antimicrobials
) covalently bound to surfaces rendered them sufficiently resistant to an Enterobacter cloacae inoculum and its adherent biofilm. Compared to unmodified surfaces, up to a 30-fold reduction in bacterial attachment was achieved with this coating technology. The immobilization of chlorhexidine was verified with infrared reflection absorption spectroscopy (IRRAS) and X-ray photoelectron spectroscopy (XPS), and a leaching test was performed to confirm that the chlorhexidine molecules were not dislodged. Cell compatibility was examined by culturing fibroblasts and osteoblasts on the modified surfaces, revealing greater than 93% cell viability. This coating technology may be broadly applicable for a wide range of other antibacterial agents and allow the design of new biomaterials.
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