Comparison of the Effects of Various Peroxisome Proliferators on Peroxisomal Enzyme Activities, DNA Synthesis, and Apoptosis in Rat and Human Hepatocyte Cultures

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

Susanna S.T. Lee, Thierry Pineau, John Drago et al. · Molecular and Cellular Biology · 1995 · 1.6K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +16

Preparation of rat liver cells

Per O. Seglen · Experimental Cell Research · 1973 · 1.1K citations

Medicine, Biochemistry, Cell Biology +9

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

Talia Sher, Hua Yi, O. Wesley McBride et al. · Biochemistry · 1993 · 516 citations

Life Sciences, Molecular Biology, Molecular Genetics +11

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643

J. Peters · Carcinogenesis · 1997 · 486 citations · Full text

Pharmacy, Pharmacology, Toxicology +15

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.

Daniel S. Marsman, Russell C. Cattley, James G. Conway et al. · PubMed · 1988 · 356 citations

Pharmacy, Toxicology, Carcinogenesis +15