Organic Letters · 2005 · 69 citations · 16 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCarboxylic AcidsCatalytic MechanismsHeterocycle SynthesisOrganic SynthesisRetrosynthetic AnalysisBenzofuran ChemistryBenzoic Acid DerivativesCarboxylic Acid Derivative SynthesisCarboxylic Acid FormationCarboxylic Acid SynthesisFuran ChemistryFuran SynthesisLabeling
[reaction: see text] Benzo[b]furan-3-carboxylic acid (2) was generated from 1 by forming three new bonds in one step via a Pd(II)-mediated cascade carboxylative annulation. The proposed mechanism was supported by the observation of an unusual acetylation of 1 as a side reaction together with an (18)O-labeling study.
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