Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

James G. Rheinwatd, Howard Green · Cell · 1975 · 4.5K citations

Life Sciences, Cell Biology, Microbiology +6

Microscale culture of human liver cells for drug development

Salman R. Khetani, Sangeeta N. Bhatia · Nature Biotechnology · 2007 · 1.2K citations

Engineering, Biotechnology, Cell Biology +14

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.

Ziad Abdel‐Razzak, Pascal Loyer, Alain Fautrel et al. · Molecular Pharmacology · 1993 · 535 citations

Medicine, Biochemistry, Pharmacology +17

Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P450 2C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes

Alison E. Aitken, Edward T. Morgan · Drug Metabolism and Disposition · 2007 · 394 citations · Full text

Life Sciences, Pharmacology, Toxicology +17

Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.

Cem Gabay, Michael F. Smith, Denise M. Eidlen et al. · Journal of Clinical Investigation · 1997 · 315 citations · Full text

Life Sciences, Cell Biology, Immunology +16