PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

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D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Neurological Disorder +7

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

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Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells

Atsuro Miyata, Akira Arimura, Raymond R. Dahl et al. · Biochemical and Biophysical Research Communications · 1989 · 1.8K citations

Pituitary Cells, Molecular Physiology, Residue-hypothalamic Polypeptide +12

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

Albrecht M. Clement, Minh Dang Nguyen, Elizabeth A. Roberts et al. · Science · 2003 · 1.1K citations

Motor Dysfunction, Cellular Neurobiology, Social Sciences +18

Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38)

Atsuro Miyata, Lun Jiang, Raymond D. Dahl et al. · Biochemical and Biophysical Research Communications · 1990 · 922 citations

Signal Transduction, Molecular Neuroscience, Molecular Physiology +12