The Efficacy and Safety of Crataegus Extract WS® 1442 in Patients with Heart Failure: The SPICE Trial

Abstract

In this study, WS 1442 had no significant effect on the primary endpoint. WS 1442 was safe to use in patients receiving optimal medication for heart failure. In addition, the data may indicate that WS 1442 can potentially reduce the incidence of sudden cardiac death, at least in patients with less compromised left ventricular function.