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The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure

The Digitalis Investigation Group

New England Journal of Medicine · 1997 · 3K citations · 5 references

DOIFull text

Open access

Abstract

Digoxin did not reduce overall mortality, but it reduced the rate of hospitalization both overall and for worsening heart failure. These findings define more precisely the role of digoxin in the management of chronic heart failure.

References

5

Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

Milton Packer, Joseph R. Carver, Richard J. Rodeheffer et al. · New England Journal of Medicine · 1991

2.2K citations

Withdrawal of Digoxin from Patients with Chronic Heart Failure Treated with Angiotensin-Converting-Enzyme Inhibitors

Milton Packer, Mihai Gheorghiade, James B. Young et al. · New England Journal of Medicine · 1993

823 citations

Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: Results of the PROVED trial

Barry F. Uretsky, James B. Young, F.Eden Shahidi et al. · Journal of the American College of Cardiology · 1993

+6

583 citations

Rationale, design, implementation, and baseline characteristics of patients in the dig trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure

Controlled Clinical Trials · 1996

+12

130 citations

Digitalis--a new controversy regarding an old drug. The pitfalls of inappropriate methods.

Salim Yusuf, Janet Wittes, Kent R. Bailey et al. · Circulation · 1986

+12

86 citations