Induction of Cytokine Expression in Leukocytes by Binding of Thrombin-Stimulated Platelets

Abstract

In patients with AMI, leukocyte-platelet adhesion is increased. Binding of activated platelets induces IL-1 beta, IL-8, and MCP-1 in leukocytes. Our findings suggest that leukocyte-platelet adhesion contributes to the regulation of inflammatory responses in AMI.