Proceedings of the National Academy of Sciences · 1992 · 169 citations · 17 references
Life SciencesBiochemistryNeuroscienceCell SignalingSensory PhysiologySignal TransductionOlfactory NeuroscienceOlfactory PhysiologyOlfactory SystemsProtein Kinase CascadesSecond Messenger SignalingSignal Transduction PathwaysCyclic Adenosine Monophosphate PathwayCyclic Adenosine Monophosphate SignalingInositol Trisphosphate SignalingOdorant ReceptorsOlfactory Cilia FunctionOlfactory DesensitizationOlfactory TransductionPhosphorylation Regulation
By using isolated rat olfactory cilia and a fast kinetics methodology, it has been demonstrated that odorant-induced second messenger signaling in the millisecond time range is terminated via phosphorylation reactions catalyzed by specific protein kinases. The cyclic adenosine nucleotide pathway is turned off by kinase A activity, whereas the inositol trisphosphate cascade is terminated by kinase C. The data support the concept that desensitization of odorant responses involves phosphorylation of key elements in the transduction cascade.
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