Concepedia

Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative

Jack C. Slootweg, Timo B. van Schaik, H. C. Quarles van Ufford, Eefjan Breukink, Rob M. J. Liskamp, Dirk T. S. Rijkers

Bioorganic & Medicinal Chemistry Letters · 2013 · 28 citations · 20 references

Concepts

Life SciencesBiochemistryMedicinal ChemistryAntimicrobial PharmacologyMembrane BiochemistryAntimicrobial PeptidesLipid-protein InteractionsMembrane AnchoringMembrane ProteinsPeptide ChemistryProtein-lipid InteractionsAntibacterial PeptidesAntimicrobial Peptide ActivityBiological Activity FeaturesCationic Antimicrobial PeptidesHydrophobic PeptidesPeptide Structure-activity RelationshipsSubstituent Effects On Biological Activity

References

20

Antimicrobial peptides of multicellular organisms

Michael Zasloff · Nature · 2002 · 8.4K citations

Life Sciences, Biochemistry, Microbiology +10

Rational Design of α-Helical Antimicrobial Peptides with Enhanced Activities and Specificity/Therapeutic Index

Yuxin Chen, Colin T. Mant, Susan Walker Farmer et al. · Journal of Biological Chemistry · 2005 · 598 citations · Full text

Pharmacy, Biochemistry, Drug Design +16

Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections

Amanda C. Engler, Nikken Wiradharma, Zhan Yuin Ong et al. · Nano Today · 2012 · 354 citations

Life Sciences, Infectious Diseases, Microbiology +14

Louis D. Saravolatz, Stanley C. Deresinski, David A. Stevens · Clinical Infectious Diseases · 2003 · 293 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Conjugation of fatty acids with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide

A. A. Malina, Yechiel Shai · Biochemical Journal · 2005 · 187 citations · Full text

Life Sciences, Biochemistry, Microbiology +17