Pharmacology · 1997 · 10 citations · 0 references
Lipid PeroxidationRedox BiologyOxidative StressBiosynthesisReactive Nitrogen SpecieNitric Oxide SynthaseHepatotoxicityInducible IsoformHealth SciencesBiochemistryLiver PhysiologyMetabolomicsPharmacologyDrug-induced Liver InjuryLiverRat LiverHepatologyCellular EnzymologyPhysiologyLiver DiseaseMetabolismMedicineNitrosative Stress
Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by carbon tetrachloride (CCl4). This finding may have further practical implications in hepatoprotection from various noxious chemical and biological agents.