Blockade of morphine reward through the activation of κ-opioid receptors in mice

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

Charles Chavkin, Iain F. James, Avram Goldstein · Science · 1982 · 1.2K citations

Medicine, Medicinal Chemistry, Pharmacology +17

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

Rainer Spanagel, A. Herz, Toni S. Shippenberg · Proceedings of the National Academy of Sciences · 1992 · 1K citations

Life Sciences, Neuroscience, Pharmacology +16