Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors

Abstract

The synthesis and structure-activity profile of a new class of potent and highly specific thromboxane A2 synthetase inhibitors is described. The most potent member of this series in vitro is determined to be imidazo[1,5-a]-pyridine-5-hexanoic acid (9).