Generalized Epilepsy with Febrile Seizures Plus (GEFS⁺): Clinical Spectrum in Seven Italian Families Unrelated to <i>SCN1A, SCN1B</i>, and <i>GABRG2</i> Gene Mutations

Abstract

The most frequently observed phenotypes matched those reported in families with mutations of the SCN1A, SCN1B, and GABRG2 genes. IGE and GEFS+ may overlap in some families, suggesting a shared genetic mechanism. The observation that 13% of affected individuals had focal epilepsy confirms previously reported rates and should prompt a reformulation of the "GEFS+" concept to include focal epileptogenesis.