Crystal Structure Analysis of Deamino-Oxytocin: Conformational Flexibility and Receptor Binding

Abstract

Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.