Concepedia

Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

Gitte Dam, Susanne Keiding, Ole Lajord Munk, Peter Ott, Hendrik Vilstrup, Lasse K. Bak, Helle S. Waagepetersen, Arne Schousboe, Michael Sφrensen

Hepatology · 2012 · 73 citations · 24 references

DOIFull text

Open access

Abstract

The low values of CMRO(2) and CBF observed during HE increased after recovery from HE and were thus associated with HE rather than the liver disease as such. The changes in CMRO(2) and CBF could not be linked to blood ammonia concentration or CMRA.

References

24

Hepatic encephalopathy—Definition, nomenclature, diagnosis, and quantification: Final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998

Péter Ferenci, Alan H. Lockwood, Kevin D. Mullen et al. · Hepatology · 2002 · 2K citations · Full text

The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia.

Alan H. Lockwood, J. McDonald, Robert E. Reiman et al. · Journal of Clinical Investigation · 1979 · 405 citations · Full text

, , +18

Brain α‐Ketoglutarate Dehydrogenase Complex: Kinetic Properties, Regional Distribution, and Effects of Inhibitors

James C. K. Lai, Arthur J.L. Cooper · Journal of Neurochemistry · 1986 · 309 citations

Evidence of the Limitations of Water as a Freely Diffusible Tracer in Brain of the Rhesus Monkey

John O. Eichling, Marcus E. Raichle, Robert L. Grubb et al. · Circulation Research · 1974 · 278 citations

, , +24

Hyponatremia Is a Risk Factor of Hepatic Encephalopathy in Patients With Cirrhosis: A Prospective Study With Time-Dependent Analysis

Mónica Guevara, María E. Baccaro, Aldo Torre et al. · The American Journal of Gastroenterology · 2009 · 236 citations