Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Psychopharmacology, Pharmacotherapy, Synaptic Dopamine Concentrations +18

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

Rainer Spanagel, A. Herz, Toni S. Shippenberg · Proceedings of the National Academy of Sciences · 1992 · 1K citations · Full text

Mesolimbic Dopaminergic Pathway, Neurotransmitter, Dopamine Release +16

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.

R. Bals-Kubik, A. Ableitner, A. Herz et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 525 citations

Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning

Ronald F. Mucha, Albert Herz · Psychopharmacology · 1985 · 522 citations

Behavioral Decision Making, Affective Neuroscience, Sensory Science +17

Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats

Zvani L. Rossetti, Yousef Hmaidan, G L Gessa · European Journal of Pharmacology · 1992 · 519 citations

Substance Abuse, Psychoactive Drug, Substance Use +14