Asymmetric synthesis of the core structure of the Melodinus alkaloids

Use of aza-Cope rearrangement-Mannich cyclization reactions to achieve a general entry to Melodinus and Aspidosperma alkaloids. Stereocontrolled total syntheses of (.+-.)-deoxoapodine, (.+-.)-meloscine, and (.+-.)-epimeloscine and a formal synthesis of (.+-.)-1-acetylaspidoalbidine

Larry E. Overman, G.M. Robertson, Albert J. Robichaud · Journal of the American Chemical Society · 1991 · 133 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

First Asymmetric Synthesis of a Hasubanan Alkaloid. Total Synthesis of (+)-Cepharamine

Arthur G. Schultz, Aihua Wang · Journal of the American Chemical Society · 1998 · 57 citations

Pharmacy, Chemistry, Medicinal Chemistry +8

Methyleneindolines, indolenines, and indoleniniums. 20. The first biomimetic synthesis of scandine and meloscine

Georgette Hugel, Jean Lévy · The Journal of Organic Chemistry · 1986 · 35 citations

Natural Sciences, Chemistry, Medicinal Chemistry +12

Photochemistry of 4-vinyl-2,5-cyclohexadien-1-ones. A remarkable effect of substitution on the type A and dienone-phenol photorearrangements

Arthur G. Schultz, Neal J. Green · Journal of the American Chemical Society · 1992 · 26 citations

Natural Sciences, Chemistry, Analytical Chemistry +6

The first skeletal rearrangement of Aspidosperma to Melodinus alkaloids. A facile conversion of (-)-vincadifformine into N-methyltetrahydromeloscine

Bruno Danieli, Giordano Lesma, Giovanni Palmisano et al. · The Journal of Organic Chemistry · 1984 · 25 citations

Pharmacy, Biochemistry, Chemistry +9