A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Stefan Feske, Yousang Gwack, Murali Prakriya, +7

Nature

Crac Channel FunctionImmunogeneticsMolecular ImmunologyImmune DeficiencyAutoimmune Disease +8

STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx

Jen Liou, Man Lyang Kim, Won Do Heo, +4

Current Biology

PhysiologyCa2+ Sensor Essential

STIM1, an essential and conserved component of store-operated Ca2 <b>+</b> channel function

Jack Roos, Paul J. DiGregorio, Andriy V. Yeromin, +9

The Journal of Cell Biology

Depletion of intracellular calcium stores activates a calcium current in mast cells

Markus Hoth, Reinhold Penner

Nature

Signal TransductionMolecular PhysiologyCell SignalingPhysiologyMast Cells +6

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

Shenyuan L. Zhang, Ying Yu, Jack Roos, +5

Nature

Signal TransductionMolecular PhysiologyCa2+ SensorCa2+ StoreMolecular Biology +5

Orai1 is an essential pore subunit of the CRAC channel

Murali Prakriya, Stefan Feske, Yousang Gwack, +3

Nature

Protein SecretionSignal TransductionBiochemistryNatural SciencesMembrane Transport +7

CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca ²⁺ Entry

Monika Vig, Christine Peinelt, Andreas Beck, +8

Science

Protein SecretionMolecular BiologyCellular PhysiologyMembrane TransportIntercellular Communication +18

Genome-wide RNAi screen of Ca ²⁺ influx identifies genes that regulate Ca ²⁺ release-activated Ca ²⁺ channel activity

Shenyuan L. Zhang, Andriy V. Yeromin, Xiang H.-F. Zhang, +6

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyCytoskeletonSynaptic SignalingCellular Physiology +22

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

Riina M. Luik, Minnie M. Wu, JoAnn Buchanan, +1

The Journal of Cell Biology

Requirement of the Inositol Trisphosphate Receptor for Activation of Store-Operated Ca ²⁺ Channels

Hongtao Ma, Randen L. Patterson, Damian B. van Rossum, +4

Science