Identification of Seroreactive Proteins of Leptospira interrogans Serovar Copenhageni Using a High-Density Protein Microarray Approach

Carolina Lessa-Aquino, Camila B. Rodrigues, Jozelyn Pablo, Rie Sasaki, Algis Jasinskas, Li Liang, Elsio A. Wunder, Guilherme S. Ribeiro, Adam Vigil, Ricardo Galler,

PLoS neglected tropical diseases · 2013 · 45 citations · 32 references

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Abstract

Our study is the first large-scale evaluation of immunodominant antigens associated with naturally acquired leptospiral infection, and novel as well as known serodiagnostic leptospiral antigens that are recognized by antibodies in the sera of leptospirosis cases were identified. The novel antigens identified here may have potential use in both the development of new tests and the improvement of currently available assays for diagnosing this neglected tropical disease. Further research is needed to assess the utility of these antigens in more deployable diagnostic platforms.

References

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