Effects of eight antibacterial agents on cell survival and expression of epithelial‐cell‐ or cell‐adhesion‐related genes in human gingival epithelial cells

Abstract

These results suggest that little, if any, adverse effects on growth, differentiation, and adhesion of basal epithelial cells would be expected with topical administration of clarithromycin, ofloxacin or azithromycin to the periodontal pocket at a dose equivalent to the MIC90. It is important to note, however, that the extrapolation of these findings to in vivo conditions has yet to be undertaken.