Influence of intracellular folates on methotrexate metabolism and cytotoxicity

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

Herbert D. Soule, J. Vázquez, Anna Long et al. · JNCI Journal of the National Cancer Institute · 1973 · 2.5K citations

Medicine, Cell Biology, Oncology +10

New Approaches to Cancer Chemotherapy with Methotrexate

Howard L. Bleich, Emily S. Boro, E Frei et al. · New England Journal of Medicine · 1975 · 232 citations

Medicine, Oncology, Pharmacology +16

The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

Carmen J. Allegra, Robert L. Fine, J C Drake et al. · Journal of Biological Chemistry · 1986 · 137 citations · Full text

Medicine, Biochemistry, Pharmacology +10

The influence of extracellular folate concentration on methotrexate uptake by human KB cells. Partial characterization of a membrane-associated methotrexate binding protein.

Madeleine Kane, R Portillo, Patrick C. Elwood et al. · Journal of Biological Chemistry · 1986 · 77 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Characteristics of membrane transport of methotrexate by cultured human breast cancer cells

Richard L. Schilsky, Brenda D. Bailey, Bruce A. Chabner · Biochemical Pharmacology · 1981 · 49 citations

Life Sciences, Cell Biology, Pharmacology +14