Tuning the biological properties of amphipathic α-helical antimicrobial peptides: Rational use of minimal amino acid substitutions

Determination of the helix and β form of proteins in aqueous solution by circular dichroism

Yee-Hsiung Chen, Jen Tsi Yang, Kue Hung Chau · Biochemistry · 1974 · 2.1K citations

Protein Assembly, Biomolecular Structure Prediction, Altmetric Attention Score +21

The helical hydrophobic moment: a measure of the amphiphilicity of a helix

David Eisenberg, Robert M. Weiss, Thomas C. Terwilliger · Nature · 1982 · 1.1K citations

Helical Hydrophobic Moment, Protein Folding, Natural Sciences +6

Amphipathic α helical antimicrobial peptides.

Anna Giangaspero, Luca Sandri, Alessandro Tossi · European Journal of Biochemistry · 2001 · 636 citations

Rational Design of α-Helical Antimicrobial Peptides with Enhanced Activities and Specificity/Therapeutic Index

Yuxin Chen, Colin T. Mant, Susan Walker Farmer et al. · Journal of Biological Chemistry · 2005 · 586 citations · Full text

Bioorganic Chemistry, Peptide Engineering, Peptide Science +21

Optimization of the antimicrobial activity of magainin peptides by modification of charge

Margitta Dathe, Heike Nikolenko, Jana Meyer et al. · FEBS Letters · 2001 · 411 citations · Full text