Japanese Journal of Cancer Research · 1998 · 29 citations · 48 references
Life SciencesInfectious DiseasesMolecular BiologyGene ExpressionMolecular VirologyTransgenic Animal ModelsLiver DiseaseTransgene DesignViral Gene ExpressionViral HepatitisHepatitis C InfectionTransgenic Cell LinesTransgenic MiceTransgenic Mouse ModelsTransgenic Mouse ProductionTransgenic Reporter Lines
Hepatitis C virus (HCV), a major causative agent of post transfusion non-A, non-B hepatitis (NANBH), can only infect humans and chimpanzees. We produced nine transgenic mouse lines carrying a full-length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver-specific expression. In one of these lines HCV mRNA and HCV core protein were detected in the liver of the transgenic mouse, although the levels of expression were very low. In addition, HCV-related antibody was detected in the serum.
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Genetic organization and diversity of the hepatitis C virus.
Q L Choo, K H Richman, Jang H. Han et al. · Proceedings of the National Academy of Sciences · 1991 · 1.7K citations